en Nursing Original Article <p><span style="font-family:Times New Roman;"><span style="font-size:14px;"><span style="line-height:150%"><b><span style="background:white"><span style="line-height:150%"><span new="" roman="" times=""><span style="color:black">Background:</span></span></span></span></b><span style="background:white"><span style="line-height:150%"><span new="" roman="" times=""><span style="color:black"> Health-related quality of life (HRQOL) refers to perceived physical, mental, emotional, and social well-being. The purpose of this study is to evaluate HRQOL in patients with chronic respiratory failure (CRF).</span></span></span></span></span><span style="line-height:150%"><span style="background:white"><span style="line-height:150%"><span style="font-family:"Times New Roman",serif"></span></span></span></span><br> <span style="line-height:150%"><b><span style="background:white"><span style="line-height:150%"><span new="" roman="" times=""><span style="color:black">Methods:</span></span></span></span></b><span style="background:white"><span style="line-height:150%"><span new="" roman="" times=""><span style="color:black"> The present mixed methods study is conducted since 2020 by simultaneous implementation of quantitative and qualitative phases. The quantitative phase is cross-sectional research to deter</span></span></span></span></span></span></span><span style="font-family:Times New Roman;"><span style="font-size:14px;"><span style="line-height:150%"><span style="background:white"><span style="line-height:150%"><span new="" roman="" times=""><span style="color:black">mine HRQOL in patients with CRF. In this phase, 171 patients will be selected based on the inclusion criteria from the internal medicine, respiratory, and neurology wards of hospitals affiliated with the Golestan University of Medical Sciences (Gorgan, Iran). The stratified sampling method is applied by calculating the bed occupancy rate. To collect data in this phase, the Persian version of the HRQOL questionnaire will be used for patients with CRF. In addition, the questionnaire will be translated and evaluated in terms of psychometric properties. Data obtained from the quantitative phase are analyzed by descriptive statistics using SPSS 16 software. Simultaneously with the quantitative phase, the researcher will achieve an understanding of HRQOL in the patients by using the contractual content analysis method in the qualitative phase.</span></span></span></span><span style="line-height:150%"><span new="" roman="" times=""> In this phase, the subjects will be selected via Purposeful sampling. <span style="background:white"><span style="color:black">&nbsp;Data are collected through semi-structured interviews and sampling will continue until reaching data saturation. Data analysis is done by the Graneheim and Lundman method. In this regard, after extracting and categorizing the codes, subclasses and classes will be formed. Finally, the findings of the quantitative and qualitative phases will be compared and integrated for discussion and interpretation of the data.</span></span><span style="background:white"></span></span></span></span><br> <span style="line-height:150%"><b><span style="background:white"><span style="line-height:150%"><span new="" roman="" times=""><span style="color:black">Conclusion:</span></span></span></span></b><span style="background:white"><span style="line-height:150%"><span new="" roman="" times=""><span style="color:black"> Evaluation of HRQOL by implementing combined qualitative and quantitative approaches can provide a complete picture of this concept in patients with CRF. Moreover, the results of such studies can help predict outcomes and the efficacy of therapeutic interventions.</span></span></span></span></span></span></span></p> quality of life, Respiratory Insufficiency, Health , mixed methods study 56 58 http://nmj.goums.ac.ir/browse.php?a_code=A-10-1311-1&slc_lang=en&sid=1 Elyas Hosseinzadeh Younesi elyas.hy1366@yahoo.com 100319475328460014789 100319475328460014789 No Department of Nursing, Phd Condidate in Nursing Education, Golestan University of Medical sciences, Gorgan, Iran. Zahra Sabzi zsgorgan@yahoo.com 100319475328460014790 100319475328460014790 No Phd of Nursing, Assistant Professor, Nursing Research Center, Golestan University of Medical Science, Gorgan, Iran. Mahmoud Khandashpour Khandashpour2027@gmail.com 100319475328460014791 100319475328460014791 No Department of Internal Medicine, Golestan University of Medical sciences, Shahid Sayad Shirazi Hospital, Gorgan, Iran Wolfram Windisch 100319475328460014792 100319475328460014792 No Department of Respiratory Medicine, Kliniken der Stadt Köln gGmbH, University of Witten/Herdecke. Leila Teymouri Yeganeh liela1388@yahoo.com 100319475328460014793 100319475328460014793 No Graduated in Mathematical Statistics, Razi University, Kermanshah, Iran. Shohreh Kolagari kolagari4@gmail.com 100319475328460014794 100319475328460014794 Yes Phd of Nursing, Associate Professor, Nursing Research Center , Golestan University of Medical Science, Gorgan, Iran