Background and Objective: Substance abuse is a worldwide problem and converted to a big challenge for human society. The trend of this phenomenon is rapidly increasing in the world and our country . Because of quick change of substance abuse profile, a comprehensive assessment for exact identification of this phenomenon is needed. The present study was designed to evaluate the association between substance abuse route and age related factors in substance abuser.

 Material and Methods: In this cross-sectional study (2008), 120 subjects referred to the addiction clinic of Panje-Azar Hospital in Gorgan, Golestan University and medical sciences were selected via systemic random sampling. The data was gathered by a questionnaire and interview and analyzed by, using SPSS software, ANOVA and Tukey post hoc test (P<0.05).

 Results: The mean age of the subjects is 34.2±10.96, with the range of 16-66 years. The subjects are males (107 89.2%) and married (78 65%). The first Substance abuse of 87 (72.5%) is opium, which is the most commonly abused substance before withdrawal for 64.2% of the subjects. The main causes of the first use are having pleasure (38.8%), getting rid of psychological problem (23.3%) and being curios (23.3%). Sixty (50%) of them report that they first experienced it at home. The relation between age and route of substance abuse is statistically significant (P=0.025).

 Conclusion: According to rapid change in substance abuse profile and the characteristics of addicted people, periodically assessments are necessary for identifying this phenomenon and planning evidence based preventive plans.

Background and Objective: Attitude toward the use of drug has an effective role in tendency to the use and withdrawal of the drug.  This study aimed to determine the predictive role of demographic factors and personality attitudes towards the impacts, risks and Substance Abuse in the students of Azad University, Damghan Branch.

Material and Methods: This descriptive-analytic study was conducted on 200 students via convenience sampling. The  data  was collected  by Delavar Addiction  Questionnaire and NEO personality inventory , and analyzed by  Pearson correlation coefficient and multiple  regression analysis.

Results: Accordance with regression analysis, eight factors of conscientiousness, openness to experiences, neuroticism, Agreeableness, gender, household income, parental education, and age can significantly predict 41% of the variance related to the attitude toward the effects of drug. Furthermore, agreeableness, conscientiousness, neuroticism can predict 35% of the variance referring to the attitudes about the dangers of drug.

Conclusion: It can be concluded that personality characteristics, marital status and income can play  a decisive role in people's attitudes towards drugs.