Background and Objective: Non-alcoholic fatty liver disease is the most prevalent cause of hepatic related problems. , which has not been introduced any crucial treatment for it so far. Insulin resistance and oxidative stress are the most important risk factors for this disease. As anti-oxidant and insulin resistance decreasing effect of Cinnamon has been shown in prior studies, we carried out this research to determine the effect of cinnamon on lipid profile, liver enzymes, insulin resistance and hs-CRP inflammatory factor in patients with nonalcoholic fatty liver.

  Material and Methods: this clinical trial was conducted on 50 patients with fatty liver, selected on the basis of including criteria. The Intervention group was given 1.5 gram Cinnamon and placebo group taken placebo for 12 weeks. Lipid profile (triglycerides, total cholesterol, HDL and LDL), fasting blood glucose, serum insulin , hs - CRP inflammatory factor, liver enzymes (ALT and AST and GGT), insulin resistance index (HOMA-IR) and insulin sensitivity (QUICKI), diet, physical activity and anthropometric indices were measured in the beginning and end of the study. Statistical analysis was performed by SPSS software, using Covariance, Students t-test, Paired t-test, Wilcoxon and Mann-Whitney.

  Results: A significant decrease in HOMA, fasting blood glucose, total cholesterol, ALT, AST, GGT and hs-CRP , and a significant increase in Quicki were seen in Cinnamon group (p <0.05). The change of LDL cholesterol in both groups was significant (p <0.05), whereas the reduction of HDL cholesterol wasn’t significant ­­ (p=0.130).

  Conclusion: based on the results, the use of Cinnamon may be effective in the patients with non-alcoholic fatty liver disease.