en Psychology and Psychiatry Original Article <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><span style="unicode-bidi:embed"><span new="" roman="" times=""><strong>Background:</strong> Because of the numerous problems created by neurofibromatosis type 1, particular quality-of-life evaluation measures are quite significant. In Iran, general instruments are used to assess the quality of life of the target group. This study aimed to translate and examine the psychometrics of the Persian version of the Neurofibromatosis Type 1 Adult Health-related Quality of Life (NF1-AdQOL) questionnaire.</span></span><br> <span style="unicode-bidi:embed"><span new="" roman="" times=""><strong>Methods: </strong>This was a methodological and cross-sectional study. A total of 414 adult patients with neurofibromatosis type 1 in the Iranian Association of Neurofibromatosis were selected via convenience sampling. With the permission of the questionnaire&#39;s developer, the English version was translated into Persian using the standard back-translation procedure. Validity was assessed using face validity, content validity, exploratory, and confirmatory factor analysis. The reliability and internal consistency of the questionnaire were assessed by Cronbach&#39;s alpha and Spearman&#39;s correlation, respectively.</span></span><br> <span style="unicode-bidi:embed"><span new="" roman="" times=""><strong>Results: </strong>The participants&#39; mean age was 34.48&plusmn;8.3 years. The 31-item questionnaire was translated into Persian, and based on content validity analysis, 2 items were removed. The adequacy of the sample size was acceptable (KMO = 0.940). Exploratory factor analysis revealed 4 factors. The scale had good reliability (Cronbach&#39;s alpha: 0.95), and the intraclass coefficient was 0.91. The total mean quality of life score was 93&plusmn;25.18.</span></span><br> <span new="" roman="" times=""><strong>Conclusions:</strong> The finding showed that the Persian version of the questionnaire has good structural characteristics and is a reliable and valid instrument for measuring the quality of life of patients with neurofibromatosis 1.</span></span></span></div> Neurofibromatosis Type 1 Adult Health-related Quality of Life, Psychometrics, Rare diseases, Von Recklinghausen's disease 63 66 http://nmj.goums.ac.ir/browse.php?a_code=A-10-1481-1&slc_lang=en&sid=1 Reza Jahanshahi rjahanshahi75@yahoo.com 100319475328460012577 100319475328460012577 No Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran Fatemeh Mirzaei fatemehmirzaei.ir.1998@gmail.com 100319475328460012578 100319475328460012578 No Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran Mohammad Hossein Askari mohammadhossein13766@gmail.com 100319475328460012579 100319475328460012579 No Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran Nafiseh Asgari Nafiseh_asgari@yahoo.com 100319475328460012580 100319475328460012580 No Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran Shohreh Ghasemi sghasemi@augusta.edu 100319475328460012581 100319475328460012581 No Department of Augusta University, GA ,USA Akram Sanagoo sanagoo@goums.ac.ir 100319475328460012582 100319475328460012582 Yes School of Nursing and Midwifery, Golestan University of Medical Sciences, Gorgan, Iran Leila Jouybari jouybari@goums.ac.ir 100319475328460012583 100319475328460012583 No School of Nursing and Midwifery, Golestan University of Medical Sciences, Gorgan, Iran