en Psychology and Psychiatry Original Article <strong>Background</strong>: pregnancy is one of the most stressful periods a woman experiences in her life. This study was done to determine the perceived stress and prenatal distress in pregnancy and its related factors.<br> <strong>Methods:</strong> The is cohort study was carried out on 110 pregnant women whit gestational age of 24 to 28 weeks who referred to Reference laboratory in Miandoab city in 2016-2017. The sample was selected based on availability. The Cohen Perceived Stress Scale (PSS) and Prenatal Distress Questionnaire (PDQ) and demographical information were used. All obtained data were analyzed in SPSS- 23 using t test, Paired-t test and person test. Significant level was considered less than 0.05.<br> <strong>Results: </strong>The results of study show perceived stress and prenatal distress scores in 32-36 weeks have been uptrend than 24-28 weeks. Also, there was a significant relationship between wanted pregnancy with the mean stress score in 24-28 weeks (p=0.04). Also, between perceived stress score in 32-36 weeks and maternal education level (p=0.045) and between the distress score in 24-28 weeks pregnant and the wanting the sex of the fetus by the women<span dir="RTL">.</span> (p=0.045)<br> <strong>Conclusions:</strong> According to the results, stress and anxiety of pregnant women increase with approaching delivery time; caregivers should be taken into consideration by pregnant women. In addition, the results of the study show the importance of holding educational classes and raising women&rsquo;s&#39; awareness of pregnancy and childbirth and having a planned pregnancy to reduce stress and distress. Stress, Distress, Pregnancy 67 80 http://nmj.goums.ac.ir/browse.php?a_code=A-10-1073-2&slc_lang=en&sid=1 Soheila Rabipoor 10031947532846006638 10031947532846006638 No Faculty of Nursing and Midwifery, Urmia University of Medical Sciences, Iran. Maryam Abedi m.abedi931@gmail.com 10031947532846006639 10031947532846006639 Yes Faculty of Nursing and Midwifery, Bonab Islamic Azad University, Iran.